protein c deficiencies การใช้

• This disease has similar symptoms to protein C deficiency.
• These infants often have protein C deficiency as well.
• Ms . Miller takes medication monthly for Lupus, an autoimmune disorder, and protein C deficiency.
• Therefore, DNA testing for protein C deficiency is generally not available outside of specialized research laboratories.
• Studies have demonstrated an increased risk of recurrent venous thromboembolic events in patients with protein C deficiency.
• The frequency of protein C deficiency among asymptomatic individuals is between 1 in 200 and 1 in 500.
• The majority of people with protein C deficiency lack only one copy of the functioning genes, and are therefore heterozygous.
• Warfarin necrosis is an acquired protein C deficiency due to treatment with warfarin, which is a vitamin K antagonist and an anticoagulant itself.
• The human protein C gene ( PROC ) comprises 9 exons, and protein C deficiency has been linked to over 160 mutations to date.
• The incidence of protein C deficiency in individuals who present with clinical symptoms has been reported to be estimated at 1 in 20, 000.
• Protein C deficiency may cause purpura fulminans, a severe clotting disorder in the newborn that leads to both tissue death and bleeding into the skin and other organs.
• In these situations, warfarin may be restarted at a low dosage to ensure that the protein C deficiency does not present before the vitamin K coagulation factors II, IX and X are suppressed.
• Since the clot-promoting effects of starting administration of coumadins are transitory, patients with protein C deficiency or previous warfarin necrosis can still be restarted on these drugs if appropriate measures are taken.
• Before 1999, only sixteen cases of " homozygous " protein C deficiency had been described ( two abnormal copies of the gene, leading to absence of functioning protein C in the bloodstream ).
• Examples of genetic tendencies include protein C deficiency, protein S deficiency, the Factor V Leiden mutation, hereditary anti-thrombin deficiency and prothrombin mutation G20210A . An important non-genetic risk factor is the use of estrogen-containing ( combined ) forms of hormonal contraception.
• Protein C in plasma in the steady state has a half life of 6-to 10-hour, therefore, patients with severe protein C deficiency and presenting with purpura fulminans can be treated acutely with an initial bolus of protein C concentrate 100 IU / kg followed by 50 IU / kg every 6 hours.